A novel class of small molecule inhibitors of HDAC6. Inks ES, Josey BJ, Jesinkey SR, Chou CJ. ACS chemical biology. 2012; 7(2):331-9.
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. Alsarraf O, Fan J, Dahrouj M, Chou CJ, Menick DR, Crosson CE. Exp Eye Res. 2014; 127:124-31.
Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction. Mani SK, Kern CB, Kimbrough D, Addy B, Kasiganesan H, Rivers WT, Patel RK, Chou JC, Spinale FG, Mukherjee R, Menick DR. Am J Physiol Heart Circ Physiol. 2015; 308(11):H1391-401.
HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. Circ Heart Fail. 2015; 8(6):1094-104.
Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia. McClure JJ, Zhang C, Inks ES, Peterson YK, Li J, Chou CJ. Journal of medicinal chemistry. 2016; 59(21):9942-9959.
Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor. Zhang C, Chou CJ. Organic letters. 2016; 18(21):5512-5515.
Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR. Nucleic Acids Res. 2016; 44(8):3610-7.
Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. Li X, Peterson YK, Inks ES, Himes RA, Li J, Zhang Y, Kong X, Chou CJ. J Med Chem. 2018 Mar 22;61(6):2589-2603.
Design of hydrazide-bearing HDACIs based on panobinostat and their p53 and FLT3-ITD dependency in anti-leukemia activity. Xiaoyang Li, Yuqi Jiang, Yuri K. Peterson, Xu Tongqiang, Richard A. Himes, Luo Xin, Guilin Yin, Elizabeth S. Inks, Nathan Dolloff, Stephanie Halene, Sherine S. L. Chan, and C. James Chou. Journal of Medicinal Chemistry. Accepted Manuscript. PMID: 32321249.
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. Alsarraf O, Fan J, Dahrouj M, Chou CJ, Menick DR, Crosson CE. Exp Eye Res. 2014; 127:124-31.
Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction. Mani SK, Kern CB, Kimbrough D, Addy B, Kasiganesan H, Rivers WT, Patel RK, Chou JC, Spinale FG, Mukherjee R, Menick DR. Am J Physiol Heart Circ Physiol. 2015; 308(11):H1391-401.
HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. Circ Heart Fail. 2015; 8(6):1094-104.
Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia. McClure JJ, Zhang C, Inks ES, Peterson YK, Li J, Chou CJ. Journal of medicinal chemistry. 2016; 59(21):9942-9959.
Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor. Zhang C, Chou CJ. Organic letters. 2016; 18(21):5512-5515.
Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR. Nucleic Acids Res. 2016; 44(8):3610-7.
Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. Li X, Peterson YK, Inks ES, Himes RA, Li J, Zhang Y, Kong X, Chou CJ. J Med Chem. 2018 Mar 22;61(6):2589-2603.
Design of hydrazide-bearing HDACIs based on panobinostat and their p53 and FLT3-ITD dependency in anti-leukemia activity. Xiaoyang Li, Yuqi Jiang, Yuri K. Peterson, Xu Tongqiang, Richard A. Himes, Luo Xin, Guilin Yin, Elizabeth S. Inks, Nathan Dolloff, Stephanie Halene, Sherine S. L. Chan, and C. James Chou. Journal of Medicinal Chemistry. Accepted Manuscript. PMID: 32321249.
